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miR-488-5p and its role in melanoma
Arnold, J.; Engelmann, J.C.; Schneider, N.; Bosserhoff, A.K.; Kuphal, S. (2020). miR-488-5p and its role in melanoma. Experimental and Molecular Pathology 112: 104348. https://dx.doi.org/10.1016/j.yexmp.2019.104348
In: Experimental and Molecular Pathology. ACADEMIC PRESS INC ELSEVIER SCIENCE: San Diego. ISSN 0014-4800; e-ISSN 1096-0945, more
Peer reviewed article  

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Author keywords
    Melanoma microRNA Wnt/ß-catenin pathway

Authors  Top 
  • Arnold, J.
  • Engelmann, J.C., more
  • Schneider, N.
  • Bosserhoff, A.K.
  • Kuphal, S.

Abstract
    Due to their ability to regulate dozens to hundreds of target genes simultaneously and, therefore, influence several oncogenic pathways at the same time, microRNAs are a fascinating research object in melanoma. MicroRNAs have been identified as regulators of tumor proliferation, invasion and metastasis in melanoma.More precisely, it has been published that dysregulation of miR-488 contibutes to the progression of several cancer entities. However, the biological functions of miR-488, in special miR-488-5p in melanoma, remain unclear.This study showed the involvement of miR-488-5p in Wnt/β-catenin pathway and the function as a tumor suppressor. Transfection of miR-488-5p mimic led to inhibition of proliferation, migration, anchorage independent growth and led to induction of apoptosis.These data indicated that miR-488-5p acts as a tumor suppressor and is lost during melanoma development. The loss of miR-488-5p was confirmed in vivo by in situ hybridization on melanoma tissue.

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